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Add mutect2 as a caller - #357

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caller/mutect2
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nvnieuwk wants to merge 12 commits into
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caller/mutect2

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@nvnieuwk

@nvnieuwk nvnieuwk commented Sep 8, 2026

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This PR adds a new caller: gatk Mutect2. This expands the current selection of somatic variant callers.

Two new parameters were added:
--panel_of_normals and --panel_of_normals_tbi which are optional parameters used to specify a panel of normals for mutect2

@nvnieuwk
nvnieuwk marked this pull request as draft September 8, 2026 09:09
@matthdsm

matthdsm commented Sep 8, 2026

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Would it make sense to start differentiating between somatic/germline subwf here?

@nvnieuwk

nvnieuwk commented Sep 8, 2026

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Would it make sense to start differentiating between somatic/germline subwf here?

I'm actually not sure we would really need differentiate this. Especially at this point since it's just a draft PR. I'm more thinking about doing something similar you did to the preprocessing pipeline and make all options sample-specific so users can configure the pipeline in whatever way they want

@matthdsm

matthdsm commented Sep 8, 2026

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@nvnieuwk

nvnieuwk commented Sep 9, 2026

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Currently VCF2DB does not work because bcftools norm does not correctly normalize FORMAT fields. I'll look into this later

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