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Novel Application of Stereotaxically Guided Dental Germinative 
Photodynamic Regulation in Chinchilla lanigera with 
Refractory Malocclusion.

Authored and Developed by Daniel B. B. Fraser

DOI: https://doi.org/10.5281/zenodo.18203469

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

This repository contains an open-source paper which covers photodynamic
therapy as a potential treatment option for refractory malocclusion
cases in chinchillas and other elodonts, particularly in cases of 
excessive growth, inadequate wear, and retrograde elongation.

There is also supporting documentation providing details on a
patient-specific stereotaxic device, dubbed Auriel, which was designed
to provide a stable, secure platform for the procedure. The model files
for this device are not released, to prevent it from being used against
advisement on chinchillas that it was not designed for.

Lastly, there is an attached software package for the validation of MCX
simulations graphed in the appendix of the paper. These are validation
structures with exact command line arguments for the user to enter, to
allow for exact reproducibility.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Further details on the software package can be found in the readme files
contained in each subfolder.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

License & Copyright

This project is dual-licensed due to scope:

Software code (Python Scripts) are licenced under the GNU General Public
License v3.0 (GPLv3). You may copy, distribute, and modify the software as
long as you track the changes and release modifications under the same 
license.

Documentation and Papers (PDFs, Protocol Text, and Guide Specifications) 
are licensed under Creative Commons Attribution-ShareAlike 4.0
International (CC BY-SA 4.0). To view a copy of this license, visit 
https://creativecommons.org/licenses/by-sa/4.0/

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Bibliography

The following works were cited in the development of this protocol,
hardware design, and simulation. For a formatted list with embedded links
download the main paper PDF, which is listed under the name
"Fraser_dGPR_Chinchilla_Protocol_2025_RELEASE.pdf"

Agostinis, P. et al. (2011). Photodynamic Therapy of Cancer: an Update. CA: a Cancer Journal for Clinicians, 61, 250-281. https://doi.org/10.3322/caac.20114

Anderson, R. R. & Parrish, J. A. (1983). Selective Photothermolysis: Precise Microsurgery by Selective Absorption of Pulsed Radiation. Science, 220(4596), 524-527. https://doi.org/10.1126/science.6836297

Bisland, S. K. & Burch, S. (2006). Photodynamic Therapy of Diseased Bone. Photodiagnosis and Photodynamic Therapy, 3(3), 147-155. https://doi.org/10.1016/s1572-1000(06)00036-6

Brenner, S. Z. G. et al. (2005) Clinical Anatomy, Radiography, and Computed Tomography of the Chinchilla Skull. Compendium on Continuing Education for the Practicing Veterinarian. 27(12), 933-943.

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Harris, K. et al. (2017). Endobronchial Ultrasound-Guidance for Interstitial Photodynamic Therapy of Locally Advanced Lung Cancer – A New Interventional Concept. Journal of Thoracic Disease, 9(8): 2613-2618. https://doi.org/10.21037/jtd.2017.07.45

Hisey, E., et al. (2024). Contrast Computed Tomography Dacryocystorhinography Identifies Nasolacrimal Duct Obstruction Secondary to Chronic Dental Disease in Two Chinchilla lanigera. Veterinary Ophthalmology, 28(3). https://doi.org/10.1111/vop.13281

Kato, T., et al. (2017). Nanoparticle Targeted Folate Receptor 1-Enhanced Photodynamic Therapy for Lung Cancer. Lung Cancer 113: 59-68. https://doi.org/10.1016/j.lungcan.2017.09.002

Krammer, B. (2001). Vascular Effects of Photodynamic Therapy. Anticancer Research 21(6B), 4271-4277.

Legendre, L. F. J. (2002). Malocclusions in Guinea Pigs, Chinchillas and Rabbits. The Canadian Veterinary Journal or La Revue Veterinaire Canadienne, 43(5), 385-390. 

Lennox, A. M., et al. (2021). 36 - Small Mammal Dentistry. Ferrets, Rabbits, and Rodents, 4th Edition: 514-535. ISBN 9780323484350, https://doi.org/10.1016/B978-0-323-48435-0.00036-8

Lovell, J. F. et al. (2011). Porphysome Nanovesicles Generated by Porphyrin Bilayers for Use as Multimodal Biophotonic Contrast Agents. Nature Mater, 10, 324-332. https://doi.org/10.1038/nmat2986

Mans, C. & Donnelly, T. M. (2021). 22 - Chinchillas. Ferrets, Rabbits, and Rodents, 4th Edition: 298-322. ISBN 9780323484350, https://doi.org/10.1016/B978-0-323-48435-0.00022-8

Natural History Museum of Los Angeles County (2020). Chinchilla lanigera Skull DICOM [Data Set]. MorphoSource. https://www.morphosource.org/concern/media/000114253

Philp, L. et al. (2019). Use of Porphysomes to Detect Primary Tumour, Lymph Node Metastases, Intra-Abdominal Metastases and as a Tool for Image-Guided Lymphadenectomy: Proof of Concept in Endometrial Cancer. Theranostics 9(9). 2727-2738. https://doi.org/10.7150/thno.31225

Ritzman, T. (2014). Diagnosis and Clinical Management of Gastrointestinal Conditions in Exotic Companion Mammals (Rabbits, Guinea Pigs, and Chinchillas) Veterinary Clinics of North America: Exotic Animal Practice 17(2), 179-194. https://doi.org/10.1016/j.cvex.2014.01.003

Sadar, M. J. & Mans, C. (2023). Hystricomorph Rodent Analgesia. The Veterinary Clinics of North America. Exotic animal practice 26(1) (2023): 175-186. https://doi.org/10.1016/j.cvex.2022.07.006

Sahovaler, A. et al. (2024). Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models. Cancer Research Communications 4(3), 796-810. https://doi.org/10.1158/2767-9764.crc-23-0269

Shanshool, A. S. et al. (2022). Optical Properties and Fluence Distribution in Rabbit Head Tissues at Selected Laser Wavelengths. Materials, 15(16), 5696. https://doi.org/10.3390/ma15165696

Shinn, R. et al. (2021). Feasibility and Accuracy of 3D printed patient-specific skull contoured brain biopsy guides. Veterinary Surgery, 50: 933-943. https://doi.org/10.1111/vsu.13641

Suzuki, T. et al. (2020). Vascular Shutdown by Photodynamic Therapy Using Talaporfin Sodium. Cancers 12(9), 2396. https://doi.org/10.3390/cancers12092369

Wang, L. (2018). Solute Transport in the Bone Lacunar-Canalicular System (LCS). Current Osteoporosis Reports, 16(1), 32-41. https://doi.org/10.1007/s11914-018-0414-3

Wang, W. et al. (2025). Effects of Enrofloxacin Administered Subcutaneously or Orally on the Fecal Microbiota of Chinchillas (Chinchilla lanigera). Journal of Exotic Pet Medicine 52, 9-16. https://doi.org/10.1053/j.jepm.2024.10.003

Wilcox, H. H. (1950). Histology of the Skin and Hair of the adult chinchilla. The Anatomical Record, 108(3), 385-397. https://doi.org/10.1002/ar.1091080304

About

This repository contains the paper Novel Application of Stereotaxically Guided Dental Germinative Photodynamic Regulation in Chinchilla lanigera with Refractory Malocclusion alongside a software package to validate the MCX simulations from the appendix. This is not general use code, and requires installation of the MCX package.

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